Research Scientist

As a Research Scientist, you will work closely with your Team Leader, VP of Biology, and the Head of R&D to design and formulate research plans and collaborate effectively with other team members to achieve collective goals.
From time to time, it will be required from a Research Scientist to contribute to the filing of patents that may arise from the research and support the delivery of major work programmes with external partners.,

• Apply cellular and molecular techniques to assay cell biology pathways in iPSC-derived neurons from patients.


• Study the mechanisms of action of autophagy modulators of the endolysosomal pathway in cellular models of neurodegenerative disease.


• Conduct focussed compound evaluation for correction of disease phenotypes in endolysosomal biology.


• Undertake maintenance culture and differentiation of iPSC lines into neuronal populations such dopaminergic neurons and motor neurons.


• Generate robust and reproducible experimental data by following best lab practices and guidelines.


• Maintain accurate records of experiments and data.


• Contribute to wider project planning, including ideas for new research projects.


• Determine the most appropriate methodologies to test hypotheses and identify suitable alternatives if technical problems arise.


• Select, follow, and adapt experimental protocols·.


• Gather, analyse, and present scientific data from a variety of sources.


• Contribute to internal scientific reports and the presentation of data/papers as required; and regularly contribute to lab team meetings.


• Manage own research and administrative activities, within guidelines provided by senior colleagues.


• Undertake translational research projects.


• Undertake analysis of experimental results and interpretation.


Please note, the nature of iPSC culture and differentiation, will require weekend work from time to time.


• Hold a PhD / DPhil in molecular or cellular biology.


• Extensive experience in cell culture, preferentially in stem cell (iPSC)-derived models of neurological disorders.


• Skilled with performing cellular assays such as high-content imaging, electrophysiology, multi-electrode arrays, calcium imaging.


• Skilled in molecular biology techniques (e.g. qPCR, ELISA's, western blotting).


• Good track record of peer-reviewed publications


• Skilled with analysis and interpretation of research data.


• Able to work independently to plan projects and experiments.


• Able to meet deliverable and reporting deadlines.


• Excellent interpersonal skills, communication, and organisational skills.
  
  Samsara Therapeutics is an exciting early-stage drug discovery company with the goal of developing new therapies in neuroscience, genetic diseases and extending healthy ageing. We have a technology platform that identifies new molecules and mechanisms that induce the process of autophagy.


Samsara was founded in 2018 and has operations in Oxford & Boston. We are backed by Apollo Health Ventures, a company builder and investor in longevity, and have world-renowned scientific founders who are leaders in the geroscience field.

Our exciting portfolio is growing, and we now have a vacancy for a skilled Research Scientist to grow their career with us. This is a chance to join an exciting discovery environment in one of the most interesting therapeutic areas in pharma today.

At Samsara Therapeutics, we offer our employees a flexible, fast-paced and fun environment. We are driven by hiring the best talent who share our values of patient focus, excellence, accountability, integrity, openness and an urgency to deliver.

We are an equal opportunities employer and our ethos is to respect and value people's differences and to help everyone achieve more at work, as well as in their personal lives, so that they feel proud of the part they play in our success. We strongly believe that taking care of our employees is the right thing to do, so here is what you can expect from us in return:

• Competitive pay


• Enhanced Annual Leave: 33 days paid Annual Leave (includes bank/public holidays)


• Company Pension enrolment from day one


• Group Life Assurance


• Group Critical Illness


• Private Medical Health Insurance


• Health Cash Plan


• Cycle to Work Scheme


• Tech Scheme


• Enhanced Family Policies


• Subsidized Lunches, Job Types: Full-time, Permanent


Pay: £35,000.00-£43,000.00 per year

Benefits:

• Additional leave


• Casual dress


• Company events


• Company pension


• Cycle to work scheme


• Discounted or free food


• Enhanced maternity leave


• Enhanced paternity leave


• Health & wellbeing programme


• Life insurance


• Private medical insurance


Schedule:

• Monday to Friday


Supplemental pay types:

• Bonus scheme